LYMPHOID NEOPLASIA Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis
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چکیده
*Javeed Iqbal,1 *Yulei Shen,1 *Yanyan Liu,1 Kai Fu,1 Elaine S. Jaffe,2 Cuiling Liu,1 Zhongfeng Liu,1 Cynthia M. Lachel,1 Karen Deffenbacher,1 Timothy C. Greiner,1 Julie M. Vose,3 Sharathkumar Bhagavathi,1 Louis M. Staudt,4 Lisa Rimsza,5 Andreas Rosenwald,6 German Ott,7 Jan Delabie,8 Elias Campo,9 Rita M. Braziel,10 James R. Cook,11 Raymond R. Tubbs,11 Randy D. Gascoyne,12 James O. Armitage,3 Dennis D. Weisenburger,1 Timothy W. McKeithan,3 and Wing C. Chan1
منابع مشابه
Genome-wide miRNA profiling of mantle cell lymphoma reveals a distinct subgroup with poor prognosis.
miRNA deregulation has been implicated in the pathogenesis of mantle cell lymphoma (MCL). Using a high-throughput quantitative real-time PCR platform, we performed miRNA profiling on cyclin D1-positive MCL (n = 30) and cyclin D1-negative MCL (n = 7) and compared them with small lymphocytic leukemia/lymphoma (n = 12), aggressive B-cell lymphomas (n = 138), normal B-cell subsets, and stromal cell...
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Mantle cell lymphoma (MCL) is one of the most aggressive B-cell lymphomas. Although several protein-coding genes are altered, expression signature and importance of microRNA (miRNA) have not been well documented in this malignancy. Here, we performed miRNA expression profile in 30 patients with MCL using a platform containing 515 human miRNAs. Eighteen miRNAs were down-regulated and 21 were up-...
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تاریخ انتشار 2012